If you want to keep them in your life, I'm thinking NO.
Besides, if you're serious about keeping them around/getting them back, you'll likely end up with flat characters whose traits are all positive. Personally, I haven't met any perfect people yet.
But, what about those friends & lovers who are no longer in your life?
“There was a time when our desire for each other would have landed us in an asylum or prison, had it not been sanctioned by mutual assent.” ~Krauser
Sounds like a lover's declaration, but I can honestly say that I've felt this passion for both friends & lovers (even books:)
The quote reminds me of times in my life when my emotions felt like they were river-rafting: a strong, flowing current of life. They live on in my memory, thus, however imperfectly.
Yet here we are.
Some relationships haven't withstood the test of time and some great loves are now relegated to 'we'll always love each other, but we'll never be in love with each other'.
Does understanding WHY make it any more BEARable?
My advice: Go ahead & write 'what you know, with authenticity - it's not about recreating those people on the page (unless you're writing a memoir). Of course, the quirks you observe in those around you are bound to morph & burrow into fictional characters. Many of my friends & family have asked, "Is so-and-so based on so-and-so?"
Which is fine - let them have their fun!
Personally, I make exceptions with dead people, not unlike the character of Isabelle from my first novel:
"Maybe I'll make a rule. From now on, I'll only frame dead people's paintings. It's a good rule. And it seems just as reasonable as many of the rules our society lives by."